August 2017

Reishi Mushroom and Honeysuckle

The Tranquilizing and Immune Supporting Effects of Reishi Mushroom

by Brien Quirk

Director of R & D

  • Neuro-immune effects induce sleep via serotonin

  • Increased sleep time, and non-REM sleep

  • Clinical effects in neurasthenia (mental fatigue)

  • Immune support for athletes

  • Adjuvant immune therapy

  • Bronchial cough

Reishi is known historically as the “mushroom of immortality” and the “elixir of life” in traditional Chinese medicine (TCM). The botanical name is Ganoderma lucidum  and in Chinese it is known by the name Ling Zhi. Reishi is a hard polypore mushroom that grows on a variety of hardwood trees such as white oak or maple. The mushroom is edible and soft when it is fresh, but becomes very hard upon drying. It typically has a red varnished appearance, and is found in other colors including purple, white, yellow, and black.

In TCM, Reishi is considered a Shen tonic for tonifying the spirit ( mind) and is used for removing tumors, treating deficiency fatigue, insomnia, neurasthenia (mental fatigue), and bronchial cough. It is known to have tranquilizing effects, improve memory, promote agility, and lengthen life span. The fruiting body, mycelia and spores of Ganoderma lucidum contain approximately 400 different bioactive compounds which mainly include triterpenoids, ganoderic acids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements.

Reishi is used as a tranquilizing agent based on its “An-Shen” properties which in TCM  is indicated for the treatment of restlessness, insomnia, and palpitation. In a study of how reishi influenced sleep, it was determined that the mechanism of action was related to the polysaccharides affecting an immune pathway related to TNF-alpha (Cui). When reishi was given for 3 days to mice, it significantly increased total sleep time and non-rapid eye movement. TNF-alpha levels were significantly increased in blood serum, the hypothalamus, and in the dorsal raphe nucleus, a part of the brain where serotonin is synthesized. The raphe nucleus has the function of filtering of incoming neural inputs during sleep. The novel hypnotic immune effect of reishi is a unique neuro-immune function.

In another brain related area of health, Reishi polysaccharide extract had mood and emotional health supporting effects. A study treating 132 patients for neurasthenia, which is type of mental fatigue related to depression, showed a 51.6% improvement in the reishi treatment while only 24.6% improved in the placebo group (Gao).

Reishi polysaccharide fractions have potent immune stimulating effects and documented anti-tumor activity. Reishi’s effect on Immune function was tested in 34 advanced-stage cancer patients given 1800 mg of reishi extract three times daily for 12 weeks. The treatment resulted in a significant increase in concentrations of plasma immune factors and a significant increase in natural killer cell activity, an important immune function for fighting tumors, viruses, and other invaders (Gao, 2003). Its potent anti-tumor effects have been documented in mice resulting in a 60% inhibition of sarcoma tumor growth (Zhang 2010).

A study that measured immune function in football players who were subjected to the stress of a 28-day high altitude training regimen. Reishi significantly improved T lymphocytes levels in the players subjected to intense physical activity and exposure to hypoxia (low oxygen levels). The increased levels of T lymphocytes improved cell-mediated immune function in the players (Zhang).

Draco supplies a full spectrum, water soluble, bioavailable extract of Reishi standardized to 10% polysaccharides for all of your formulating needs.

 

The flavonoid luteolin, abundant in Honeysuckle has valuable skin bioactive effects

  • Protection against photoaging (Kim)

  • Reduction in skin redness from UV exposure

  • Skin cooling to reduce thermal effects of the sun

  • Luteolin: anti-inflammatory for UV exposed skin

  • Luteolin penetrates deep into the skin

  • Antiaging effect reduces enzymatic damage of collagen by glucose (AGES)

In traditional Chinese medicine Japanese Honeysuckle is a beautiful and fragrant flowering plant used for its cooling, anti-inflammatory effects in a wide variety of inflammatory (heat) and infectious conditions. One of the active compounds found abundantly in Japanese Honeysuckle leaf and flower is the flavonoid luteolin, which has bioactive skin effects.

 

These effects include:

  • anti-inflammatory properties for UV exposed skin (Wolfle)
  • reduced enzymatic damage of collagen for antiaging (Hwang)
  • protection against photoaging (Kim)
  • reduction in skin redness from sunburn/UV exposure (Casetti)
  • skin cooling properties to reduce thermal effects of the sun (Papaliadis).

 

For highly effective results, Luteolin penetrates deep into the skin when used in the right type of ingredient formulation, according to studies showing this bioactive to be bioavailable to skin cells (Seelinger; Merfort).

Draco supplies a full spectrum, water soluble, Japanese Honeysuckle extract standardized to 10% caffeoylquinic acid for all of your personal care formulating needs.

Please call us today at (408) 287-7871 for pricing and availability!

References for both articles are available upon request.

Draco Natural Products
539 Parrott Street
San Jose, CA 95112
Tel: 408-287-7871
Fax: 408-287-8838
email: info@dracoherbs.com
web: www.draconatural.com

Disclaimer: The contents of this document is intended as background information about botanicals as a compilation of historical, ethnobotanical, traditional uses and research studies which are widely available. No health claims are made or implied from this information, and any product use should be based on the independent evaluation of actual merits to make appropriate and accurate structure function claims. This information was compiled based on interest in the current state of research background for botanicals in general, does not necessarily imply the same effect would be found for the extract sold by Draco. This information is not intended to diagnose, cure, and treat diseases in the US. Usage and claims for these products should be evaluated and used in conformance to the particular regulatory laws and statutes of countries where it is to be marketed.

© Copyright 2017, Draco Natural Products. All rights reserved.

Turkey Tail Mushroom and Arnebia Oil

Turkey Tail Mushroom
Safe, Powerful Immunity Builder

by Brien Quirk
Director of R & D

• Water extract rich in polysaccharides
• Powerful immune support
• Powerful water-soluble immune actives: PSK and PSP
• PSK and PSP are well absorbed orally
• Analgesic – good pain relief
• Supports fat loss, based on cell studies and human clinical

Turkey Tail Mushroom (TTM) has been extensively studied in other countries including Japan and China for its multiple anticancer effects and immune-restoring properties. It is one of the most common polypore medicinal mushrooms in the northern forests of China, Japan, Europe, the US and Canada, and is known in China and Japan as Yun Zhi and Kawaratake, respectively.

TTM, known botanically as Trametes versicolor, syn. Coriolus versicolor, is a medicinal mushroom widely prescribed in China for the prevention and treatment of cancer and infections. Clinically the aqueous extract displays a wide range of biological activities, including stimulating effects on various immune cells and inhibition of cancer growth (Chu). In traditional Chinese medicine, TTM is used to reduce phlegm, clear dampness (fluid accumulation, infection), heal pulmonary conditions, strengthen the musculature, increase energy, and support the chronically ill (Yang, Jong, Ying). It is also used for infections and inflammation of the upper respiratory, urinary and digestive tracts.

TTM contains two well-known protein-bound polysaccharides, known as PSK (Polysaccharide-K) and PSP (Polysaccharide-Peptide) which are some of the most promising immune factors known. These complexes induce gene expressions of several immune messengers and receptors (Ooi). PSK significantly extended survival at five years or beyond treatment in several cancers. The active PSP significantly improved the quality of life, gave measurable pain relief, and enhanced immune status in 70-97 percent of patients (Kidd).

Oral treatment with PSK led to a significant decrease in the cancer recurrence rate and increases in disease-free survival. The polysaccharides and polysaccharide-protein complexes activate many kinds of immune cells. Prostate tumors were completely blocked though oral PSP (Luk).

PSK has many bioactive effects, andprevents the loss of immune response with aging that often leads to cancer (Matsunaga). Tumors are known to depress immune function, which prevents the body’s immune system from killing the tumors. PSK given orally boosted killer T cells and competed with immunosuppressive substances in tumors. After oral dosing of PSK to rats, small and large molecular substances appeared in the blood serum showing that large molecular weight immune compounds were being absorbed (Tsukagoshi).

PSP increases interferon alpha and gamma in white blood cells 4 to 8 times higher than controls (Li). PSK expresses SOD activity and enhanced cell activity about 7-8 times the normal levels. Cancer cells are low in SOD which is thought to be related to cancer progression (Kobayashi).

TTM has other clinically studied benefits. Pain killing or analgesia can be induced by PSP through its interaction with receptors in the brain (Gong). Treatment with TTM extract relieved the symptoms of IBD. A compound in TTM known as ternatin isolated from the mushroom inhibits fat formation in fat cells. In a human clinical study for immune effects, it not only improved immunity but also helped decrease percent body fat (Tsang).

Draco manufactures a Full Spectrum Turkey Tail extract standardized to 25% polysaccharides using a proprietary water extraction process, guaranteeing high levels of immune active polysaccharides such as PSP and PSK. Please request ordering information and minimum quantities.

 

Arnebia Oil
for Topical Arthritis, Wound Healing, and Varicose Veins

• Anti-inflammatory and anti-redness
• Acne control from anti-microbial and anti-inflammatory effects
• Relieves swelling
• Helps with wound healing, tissue trauma, and bruising
• Anti-microbial against warts
• Might help prevent varicose veins

Arnebia can help control acne because of its potent anti-microbial effects according to traditional Chinese medicine. It has been shown to be effective against a wide range of bacteria, including dangerous skin pathogens including MRSA Staph infection. Its anti-inflammatory effects have made it effective for treating acne rosacea which is not caused by bacteria or over-active sebaceous glands, but is related to inflammation processes that cause blood vessel damage and enlargement.

As a topical arthritis rub, Arnebia inhibits COX2 in sore joints. The activity shown by different extracts was comparable to that of the reference drug ibuprofen (Kaith; Subbaramaiah).

For anti-edema effects, Arnebia euchroma aqueous root extract blocked tissue swelling with 61.2% inhibition of comparable to that of the reference drug ibuprofen (50 mg/kg, (Kaith).

To relieve redness, swelling, trauma/tissue injuries, its active constituent Shikonin can inhibit COX 2 enzymes in skin cells. Inflammation in skin leads to redness, wrinkling, pigmentation and other skin damage (Subbaramaiah). Shikonin from Arnebia reduces biosynthesis of leukotrienes that cause redness and swelling (Wang).

For healing diabetic wounds, bedsores, and other wounds, Shikonins accelerates wound healing, capillary vessel number and collagen synthesis, along with having considerable antibacterial activity (Fujita). The extract of Arnebia euchroma contains anti-bacterial alkannin, a shikonin that is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (Shen).

The conditions that lead to varicose veins involve inflammation and vasodilation. Arnebia has both vascular constricting effects (Hu 2004) and anti-inflammatory effects (Wang 1994) which may be helpful to counteract the causes of varicose veins (Wang).

Draco manufactures a high purity Arnebia Oil for cosmetic use. Please request ordering information and minimum quantities.

Please call us today at (408) 287-7871 for pricing and availability!

References for both articles are available upon request.

Draco Natural Products
539 Parrott Street
San Jose, CA 95112
Tel: 408-287-7871
Fax: 408-287-8838
email: info@dracoherbs.com
web: www.draconatural.com

Disclaimer: The contents of this document is intended as background information about botanicals as a compilation of historical, ethnobotanical, traditional uses and research studies which are widely available. No health claims are made or implied from this information, and any product use should be based on the independent evaluation of actual merits to make appropriate and accurate structure function claims. This information was compiled based on interest in the current state of research background for botanicals in general, does not necessarily imply the same effect would be found for the extract sold by Draco. This information is not intended to diagnose, cure, and treat diseases in the US. Usage and claims for these products should be evaluated and used in conformance to the particular regulatory laws and statutes of countries where it is to be marketed.

© Copyright 2017, Draco Natural Products. All rights reserved.